Experience
Three decades connecting biology, computation and R&D leadership.
From research scientist in Fortune 50 pharmaceutical companies to VP of global R&D information systems, sixteen years building a computational biology company, and today’s work evaluating AI against scientific reality.
Career
Professional experience
-
2022 – 2026
Independent Consultant, Pharmaceutical Research
Self-employed · Philadelphia, PA- Advised pharmaceutical and life-science organizations on computational biology, bioinformatics and research informatics.
- Applied AI and machine-learning methods to research problems, assessing where computational output was reliable and where domain review was required.
- Developed a business plan for a start-up biotechnology company and supported its grant writing, funding strategy and research direction.
- Performed portfolio analysis for drug-discovery companies and biotechnology start-ups.
-
2006 – 2022
President & Founder
B-Tech Consulting, Ltd., d/b/a Chemalytics · Philadelphia, PA- Founded and led a company developing cloud-based algorithms and software for computational biology, chemistry and drug-discovery innovation, owning scientific direction, software architecture and business strategy across a 16-year run.
- Wrote grant proposals that secured significant NIH funding for algorithm and platform development, including NIGMS Phase I and Phase II SBIR awards for the Chemalytics cloud virtual-screening platform.
- Collaborated with pharmaceutical companies and academic research groups on cancer, HIV and antimicrobial drug-discovery programs.
- Built the scientific software stack end to end (data models, algorithm implementation, cloud delivery) and defined the data standards and validation criteria behind it.
-
2003 – 2005
Vice President, Global R&D Information Systems
Schering Geigy- Held global responsibility for bioinformatics, computational biology, and technical and scientific support for R&D worldwide.
- Directed scientific computing strategy across geographically distributed research sites, aligning platform investment with discovery priorities.
- Bridged senior scientific leadership and technical teams, translating research needs into systems and standards.
-
2000 – 2003
Director, Head of Bioinformatics
Sanofi- Led the bioinformatics function, directing computational analysis in support of discovery research programs.
- Built and managed the scientific computing capability underpinning genomics and target research.
-
1995 – 2000
Head of Bioinformatics, US
Warner Lambert- Established the computational biology capability supporting pharmaceutical discovery research.
- Applied sequence analysis, genomics and computational methods to target identification and characterization.
-
1993 – 1995
Research Fellow, Bioinformatics
National Institutes of Health- Developed and applied computational approaches to molecular biological data.
-
1991 – 1993
Postdoctoral Researcher
DuPont- Conducted research in molecular genetics and computational analysis of experimental biological data.
Grants & funding
Non-dilutive funding I wrote for and won
As founder of B-Tech Consulting, Ltd., doing business as Chemalytics, I wrote grant proposals that secured significant NIH funding, including an SBIR program from the National Institute of General Medical Sciences that took the Chemalytics cloud platform for virtual screening from a Phase I feasibility study to a Phase II award. Both phases were funded on resubmission.
FY2015 · SBIR Phase II
Cloud computing platform for virtual screening and drug discovery
NIH / NIGMS · R44GM097902-03
FY2014 · SBIR Phase IICloud computing platform for virtual screening and drug discovery
NIH / NIGMS · R44GM097902-02A1
FY2011 · SBIR Phase IApplication of cloud computing resources for virtual screening
NIH / NIGMS · R43GM097902-01A1
Award details from NIH RePORTER. Project period 2011–2017.
Capabilities
Core expertise
Scientific
Molecular geneticsComputational biologyBioinformaticsGenomicsProteomicsDrug discoveryExperimental & study design
AI & Data
AI/ML evaluationDomain validationResearch knowledge toolsResearch data platformsData standards & validation
Software & Architecture
Algorithm developmentBioinformatics pipelinesScientific software architectureCloud deliveryTechnical systems strategy
Leadership
Global R&D information systemsScientific computing strategyPortfolio managementCross-site leadershipGrants & proposalsNIH SBIR/STTR
Education
Degrees
- 1984 – 1993Ph.D., Molecular Genetics
Temple University, Philadelphia, PA - 1980 – 1984B.S., Biology
Albright College, Reading, PA
Continuing education
Certifications
- MercorIntroduction to Agents
- Claude AcademyAI Capabilities and Limitations